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Author | Topic: Rebuttal To Creationists - "Since We Can't Directly Observe Evolution..." | |||||||||||||||||||||||||||||||||||||||
Taq Member Posts: 10085 Joined: Member Rating: 5.6 |
Kleinman writes: You have no idea what a viral infection has on a germ cell. So says the person who says it will necessarily cause birth defects or death, when they actually don't. It is you who has no idea what effect a viral infection has on a germline cell.
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Taq Member Posts: 10085 Joined: Member Rating: 5.6 |
Kleinman writes: How would you know, have you examined the baby koalas that may be going extinct from a single retroviral infection? No one has reported widespread birth defects due to KoRV. You are wrong. Birth defects and failed pregnancies are not guaranteed. Also, not all retroviruses drive species to extinction. There are many retroviruses that humans are infected with, and they are not driving us to extinction. Even a very pathogenic and virulent retrovirus like KoRV is still able to be endogenized without causing fetal death or massive birth defects like you claim should happen.
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Taq Member Posts: 10085 Joined: Member Rating: 5.6 |
Kleinman writes: Yeah, they might be going extinct. You should read it in your link, you dummy. And tell me, how many viral infections have you treated? Because I have treated many, you dummy. It seems all you have to offer is name calling.
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Taq Member Posts: 10085 Joined: Member Rating: 5.6
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Kleinman writes: Now the virologist that screwed up Covid is going to tell us that germ cell infection by a retrovirus does no harm. You claimed endogenized retroviruses will necessarily cause birth defects or fetal death. You are wrong.
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Taq Member Posts: 10085 Joined: Member Rating: 5.6 |
Kleinman writes: Quit whining and read your own link, you stupid crybaby. Nowhere in my links does it state that all koalas are born with birth defects, nor does it say that endogenized KoRV is causing 100% fetal death. You are wrong.
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Taq Member Posts: 10085 Joined: Member Rating: 5.6 |
Kleinman writes: You will teach naive school children that a germ cell line can take 200k retroviral infections and it does nothing to that cell line. 200,000 retroviral infections over how many millions of years? You always seem to leave that part out.
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Taq Member Posts: 10085 Joined: Member Rating: 5.6 |
Kleinman writes: You are an idiot. You have screwed up Covid, now what else will you screw up. When you start acting like an adult, please let me know.
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Taq Member Posts: 10085 Joined: Member Rating: 5.6 |
Kleinman writes: Don't be silly. That's not what Taq's link is talking about. It is only a single infection. So let's say the koalas survive 10 generations and they get another germline infection. And another 10 generations and another germline infection, and another and another and another. They are getting HIV, followed by T-lymphocytic virus, followed by some other retrovirus, then another and another. You are under delusion to think they would survive even one infection let alone 200k infections. There are much milder viral infections that involve insertion into the host genome, such as adenovirus. You are assuming that all viral infections will kill off a species. We also have the evidence that these germline invasions happened. That evidence is the ERVs. There are about 100 human specific insertions which would have been acquired over the last 5 million years. On average, that's one ERV every 50,000 years. Of course, it was probably a bit more concentrated than that, but it isn't every 10 generations for 200k insertions. This occurred over 10's of millions of years.
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Taq Member Posts: 10085 Joined: Member Rating: 5.6 |
Kleinman writes: When you learn what a virus will do to a germline cell, let me know. I already learned. You are behind the curve because you think every single ERV will result in birth defects and fetal death. You are wrong.
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Taq Member Posts: 10085 Joined: Member Rating: 5.6 |
dwise1 writes: So the question that's left to be discussed is how a retroviral infection inserts its RNA/DNA without killing that individual cell. Reminds me of survivor bias and WW II bombers. They would map the bullet holes on bombers that made it back to the airfield, but it would have been a mistake to place more armor in those regions. Instead, you need to put armor where there were no bullet holes on the surviving planes. The same for ERVs. As you discussed, the gametes that survive are those who have the least impactful insertions. Same applies for offspring. There are also immune pathways that suppress expression of viral sequence that has entered into the genome. Subsequent mutation of ERV sequence does away with the worst effects, and can even offer some protection when copies of the endogenous viral sequence binds to complementary sequence from exogenous viral sequence and reduces the severity of infection.
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Taq Member Posts: 10085 Joined: Member Rating: 5.6 |
Kleinman writes: Who wants to hear your speculation? You have already speculated about Covid and that turned out to be a mess, and then you speculated about "mild" virus infection which you have absolutely no experience with. You have no experience in the subject even though you worked 26 years in a lab. And now you are going to tell us about 200k retroviral germline infections that don't cause any harm. You are an idiot. I see you still can't act like an adult.
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Taq Member Posts: 10085 Joined: Member Rating: 5.6
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Kleinman writes: Or maybe Taq will explain a real example of biological evolution instead of his imaginary examples. Already did. The Desai experiment where sexual reproduction alleviated clonal interference.
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Taq Member Posts: 10085 Joined: Member Rating: 5.6 |
Kleinman writes: You are a liar. You never did the mathematics of any real experiment. The mathematics are in the paper. Are you denying the results published in the paper?
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Taq Member Posts: 10085 Joined: Member Rating: 5.6
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Kleinman writes: A dimwit like you thinks that a constant environment exists for 90 generations. So why ask for real biological examples if all you are going to do is have a fit and throw toys from your pram? You talk up and down about the Lenski and Kishony experiment even though they had constant environments for way more than 90 generations. Suddenly, there's an experiment with results you don't like, and only then are constant environments a problem. Go figure.
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Taq Member Posts: 10085 Joined: Member Rating: 5.6
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Kleinman writes: The Kishony and Lenski experiments demonstrate exactly how descent with modification operates. The Lenski experiment had a constant environment for 10's of thousands of generations. Are you saying that a constant environment does not disqualify an experiment?
Desai created a special environment that increases the frequencies of adaptive alleles. How was the Desai experiment any different than the Kishony/Lenski experiment with regard to environments that increase the frequency of adaptive alleles? Also, the asexual and sexual populations in the Desai experiment were in the same environment. Clonal interference was only seen in the asexual population, not in the sexual population even though they were in the same environment. It wasn't the constant environment that caused the removal of clonal interference in the sexual population. It was recombination that alleviated clonal interference.
Descent with modification depends on the number of replications a particular variant can do. It also depends on the existence of sexual recombination, as shown in the Desai experiment.
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