Such changes as are observable are quite dramatic in some species, but all remain simply variations of the species or Kind.
Well, firstly, there's no such thing as "kind", and moreover, you're wrong. Adaptive changes can and do give rise to
new species, not just varying individuals in the old ones. It's observed fact.
Example of variation built into the original squirrel genome.
You're right that variation appears to be built into our genome; in fact, there was so much capability for variation "built into" the first organism that it gave rise to all observed species. Pretty cool.
Doesn't that prove that what produces a new "species" is far from what evolution predicts as that cat has no more potential to evolve whatever.
How do you figure? The cheetah's alleles are no more "hard-wired" than any other species. There's simply less variation, currently, among cheetahs than other cats because all living cheetahs are the decendants of a very limited gene pool, as the result of a near-extinction.
If cheetah populations increase (I don't know if they are right now or not; I rather doubt it as human expansion has been very hard on the big cats) then the variation between individual cheetahs will increase thanks to mutation. If it increases enough, and gene flow is interrupted between two subgroups, a new species of cheetah will arise. Happens all the time.
All potentials already present in the species, brought to the fore by natural selection, or in this case domestic selection and whatever else is done to the genes.
All DNA sequences have the "potential", thanks to mutation, to become any other sequence. As the only thing that separates one species from another, no matter how different, is the sequence of their DNA, all organisms have the capability or potential for rpecisely the sort of long-term change that evolution describes.
What I make of it is that by domestic breeding programs you have selected a genetically vulnerable type with very low genetic variability, which is what most "speciation" amounts to, like the cheetah, all examples of a reduction in genetic potential which works in the opposite direction from what would be necessary for evolution to occur.
Er, no, you can't reduce genetic potential. You can reduce the number of actual alleles, but you can never reduce the number of
potential alleles in a gene pool, as mutation bestows DNA with the capability to give rise to literally any allele whatsoever.
It's a different "species" only by definition not in reality.
Shocking truth time: in reality, there
are no species.