Rei writes:
The structures of no land animal alive, just scaled up in the way that the animals grow during their life, could bear the weight of such a massive body.
Which is why human 'giants', both tall and overweight, often have problems walking. Our bone structure and design simply can't support that much extra weight.
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He hoped and prayed that there wasn't an afterlife. Then he realized there was a contradiction involved here and merely hoped that there wasn't an afterlife.
- Douglas Adams, The Hitch Hiker's Guide to the Galaxy