In fact, I would suspect that most drain uncloggers are made with strong bases such as sodium hydroxide.
When I was a kid I used to augment the weak chemistry sets I got for Christmas with household chemicals including drain cleaners, ammonia solutions, bleach, etc.
Drano is sodium hydroxide with little bits of aluminum it it. The reaction when water is added is to generate intense heat and a vigorous gas release. I'm sure that the heat and the alkalinity worked on the clog.
On the other hand, there are some liquid drain cleaners that consist of a very strong solution of sulfuric acid and not much of anything else. Sulfuric acid also releases lots of heat when added to water. The acid also dissolves fat and grease. Of course you are introducing some pretty toxic stuff into your water system.
Mixing sulfuric acid with drano is a bloody stupid idea. As a kid I always wondered what would happen if I poured liquid drain clear into a can of drano, but I never got the nerve to do it.
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