Of course. Why on earth wouldn't I? There comes a point where you have all the money you really need. Were I to become extremely wealthy, my goal would be to give it away.
On a personal note. When my parents died, I inherited a bit of money. Nothing even remotely approaching "wealthy" ... the low 5 figures.
The minute the $$$ hit my account, I called my best friend and said, "How much would it take to get you debt-free?" (We were both in our mid 20s and struggling). I wired the money that day.
Money is nothing but a way to help people.