We seem to get hung up on these few cases where we seem to be overcoming natural selection.
I think this shows a misunderstanding of what is going on. Each one of the 6 billion of us is a tiny experiment in selection. There are countless things going on that we don't see.
We think that curing an illness for a few million people will have a large, long term affect on the direction of the human gene pool? I thin k not. It is too big for that and too complex.
Everytime someone walks in a modern city selection may be happening out of our ken. Does one person survive because they are a bit better able to detect the noise of an approaching car in traffic? Did they fight off the virus they were exposed to in the elevator? Did they "get lucky" because they happen to have a pattern of speech which is popular in their local city? Who the hell knows?
We may well start to directly tinker with our genetic makeup. Then perhaps, at great peril, we might take a hand in our genetic direction. In the meantime I doubt that we will consciously be able to steer it by attempting to by pass the unseen hand of selection taking place all around us.