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Author Topic:   first genetic material
molbiogirl
Member (Idle past 2699 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 11 of 84 (440788)
12-14-2007 3:38 PM
Reply to: Message 10 by Hyroglyphx
12-14-2007 3:10 PM


Re: Fortuitous happenstances
I'd say that one should start out with all the amino acids and necessary peptide bonds to make a single protein.
A protein is not life, Juggs.

This message is a reply to:
 Message 10 by Hyroglyphx, posted 12-14-2007 3:10 PM Hyroglyphx has replied

Replies to this message:
 Message 12 by Hyroglyphx, posted 12-14-2007 3:42 PM molbiogirl has replied

  
molbiogirl
Member (Idle past 2699 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 13 of 84 (440791)
12-14-2007 3:53 PM
Reply to: Message 12 by Hyroglyphx
12-14-2007 3:42 PM


Re: Fortuitous happenstances
We've known about the abiogenetic production of peptides for 30 years, Juggs.
Miller, S. L. & Orgel, L. E. The Origins of Life on the Earth (Prentice Hall, Englewood Cliffs, NJ, 1974).
Fox, S. W. & Dose, K. Molecular Evolution and the Origin of Life (Dekker, New York, 1977).
We've known about self-replicating peptides for over 10 years.
Severin K, Lee DH, Kennan AJ, and Ghadiri MR, A synthetic peptide ligase. Nature, 389: 706-9, 1997
Lee DH, Granja JR, Martinez JA, Severin K, and Ghadri MR, A self-replicating peptide. Nature, 382: 525-8, 1996
Since you don't have access to these journals, here's a sample:
The production of amino acids and their condensation to polypeptides under plausibly prebiotic conditions have long been known. But despite the central importance of molecular self-replication in the origin of life, the feasibility of peptide self-replication has not been established experimentally [3-6]. Here we report an example of a self-replicating peptide. We show that a 32-residue alpha-helical peptide based on the leucine-zipper domain of the yeast transcription factor GCN4 can act autocatalytically in templating its own synthesis by accelerating the thioester-promoted amide-bond condensation of 15- and 17-residue fragments in neutral, dilute aqueous solutions. The self-replication process displays parabolic growth pattern with the initial rates of product formation correlating with the square-root of initial template concentration.
Lee et. al, 1996.

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 Message 15 by JRTjr, posted 12-23-2007 11:51 PM molbiogirl has replied

  
molbiogirl
Member (Idle past 2699 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 17 of 84 (443214)
12-24-2007 1:08 AM
Reply to: Message 16 by JRTjr
12-24-2007 12:43 AM


Cells? Try RNA.
An individual protein has one to three hundred of these (12) amino acids; and a protein is just one small component of the cell.
Hey. Guess what, pal?
A cell wasn't the first form of "life".
RNA was.
Proteins are a moot point.
You will notice that the title of the thread is "The First Genetic Material".
RNA. Ribonucleic Acid. AKA genetic material.
Proteins are OT, my friend.

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 Message 16 by JRTjr, posted 12-24-2007 12:43 AM JRTjr has seen this message but not replied

  
molbiogirl
Member (Idle past 2699 days)
Posts: 1909
From: MO
Joined: 06-06-2007


Message 18 of 84 (443219)
12-24-2007 1:19 AM
Reply to: Message 15 by JRTjr
12-23-2007 11:51 PM


Re: Fortuitous happenstances
Miller and Robertson. Huh.
Are you referring to this?
Michael P. Robertson and Stanley L. Miller, "An Efficient Prebiotic Synthesis of Cytosine and Uracil," Nature, 375 (1995), pp. 772-774.
Golly gee willikers, youse gots me stumped!
Oh. Wait a minute.
You mean to say there been research done in the last 12 years???
A Possible Path to the RNA World: Enantioselective and Diastereoselective Purification of Ribose
Volume 37, Number 2 / April, 2007
Origins of Life and Evolution of Biospheres
The search for missing links between self-replicating nucleic ACIDs and the RNA world
Origins of Life and Evolution of Biospheres
Issue Volume 25, Number 6 / December, 1996
The emergence of the non-cellular phase of life on the fine-grained clayish particles of the early Earth's regolith
Biosystems
Volume 42, Issues 2-3, 1997, Pages 111-118
There are 161 other cites, but I think that would be a bit much.
Care to debate the particulars?

This message is a reply to:
 Message 15 by JRTjr, posted 12-23-2007 11:51 PM JRTjr has seen this message but not replied

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