quote:
Has there ever been a regression within evolution? Has anything gotten worse as a result of evolution?
"Worse" depends entirely upon the environmental circumstances.
Sickle Cell Disease certainly makes life "worse" for many people who have the genetic condition who are also living in non-malarial places.
However, if it wasn't for the mutation that results in Sickle Cell Disease, humans might have been wiped out in malarial places. So, in that regard, having SCD is "better", at least for being able to survive beyond childhood and live long enough to reproduce (Malaria is a big killer of children).