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Author Topic:   The great basic question of science on origin of life
Vladimir Matveev
Junior Member (Idle past 2324 days)
Posts: 25
From: St.Petersburg, Russia
Joined: 11-08-2015

Message 1 of 4 (776424)
01-13-2016 12:54 AM

The great basic question of science: Membrane compartment or non-membrane phase compartment (biophase) is a physical basis for origin of life?
Matveev V.V. 2016. Comparison of fundamental physical properties of the model cells (protocells) and the living cells reveals the need in protophysiology. International Journal of Astrobiology, Page 1-8.
Stable URL: Comparison of fundamental physical properties of the model cells (protocells) and the living cells reveals the need in protophysiology | International Journal of Astrobiology | Cambridge Core
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The Biophase is the Physical Basis of Life
Comments and critisim are welcome.
1. If life originated in seawater, the origin of the first cell inevitably comes down to the origin of the sodium pump and any structure supporting it — the lipid membrane — without which the work of any pump would make little sense.
2. Since the sodium-potassium pump (Na+/K+-ATPase) was discovered, no molecular model has been proposed for a predecessor of the modern sodium pump. Neither Miller’s electrical charges, nor Fox’s amino-acid condensation, nor building ready-made biomolecules into coacervates; none of this has managed to lead to the self-origination of the progenitor of the ion pump even in favourable lab conditions.
3. In 2007, we saw the simultaneous release of two articles, in which it was posited that life originated not in seawater as previously thought, but in smaller bodies of water with a K+/Na+ ratio necessary to sustain life. In this conditions sodium pump is not needed and the pump can originate later. But why the pump is needed if K+/Na+ ratio is good? The origin of the sodium pump in conditions where there is no natural need for it may require the agency of Providence.
4. Potassium Big Bang on Earth instead of potassium ponds.
5. Fox's microspheres do not need potassium ponds.
6. Despite the fact that Fox's microspheres have no fully functional membrane with sodium pumps and specific ion channels, they generate action potentials similar to that by nerve cells and in addition have ion channels which open and close spontaneously. This ability of the microspheres contradicts to the generally accepted ideas about the mechanism of generation of biological electrical potentials.
7. Hodgkin-Huxley model of action potentials is similarly well-compatible with both the nerve cell and Fox’s microsphere.
8. Biophase as the main subject of protophysiology. In the past they considered the living cell as a non-membrane phase compartment with different physical properties in comparison to the surrounding medium, and this physical difference plays a key role in cell function. According to a new take on an old phase, non-membrane phase compartments play an important role in the functioning of the cell nucleus, nuclear envelope and then of cytoplasm. Somebody sees the compartments even as temporary organelles. According to available data, the phase compartments can play a key role in cell signaling. In this historical context, studies in recent years dedicated to non-membrane phase compartments in the living cells sound sensational.
9. It is essentially a Protocell World which weaves known RNA World, DNA World and Protein World into unity.
10. In the view of non-membrane phase approach, the usage of liposomes and other membrane (non-biophase) cell models to solve the issue of the origin of life is a deadlock way of the investigation.
Edited by Vladimir Matveev, : No reason given.

Replies to this message:
 Message 2 by Admin, posted 01-13-2016 8:06 AM Vladimir Matveev has replied

Vladimir Matveev
Junior Member (Idle past 2324 days)
Posts: 25
From: St.Petersburg, Russia
Joined: 11-08-2015

Message 3 of 4 (776432)
01-13-2016 9:00 AM
Reply to: Message 2 by Admin
01-13-2016 8:06 AM

Are added details enough?

This message is a reply to:
 Message 2 by Admin, posted 01-13-2016 8:06 AM Admin has seen this message but not replied

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