It’s almost amusing that you think you’ve defeated my arguments, if it wasn’t so . so sad.
All you’ve done is show, quite vehemently, that your understanding of DNA replication and repair is, at best, surface orientated.
Again, the 10** -09 was always in the context of defining the inherent dna copying mechanism in the human cell over huge populations and long time periods as in the Genome Project.
More accurately, it is in the context of the inherent DNA copying mechanism
for point mutations.
STR mutations ARE due to the inherent DNA copying mechanism. Look it up .
You introduced all the other sources of mutation rates which are variant depending on a lot of variables that are difficult to isolate.
Could you explain this statement . it just sounds like an excuse to me. All cellular processes have variables
including DNA replication and repair. Nothing occurs in isolation.
Hey I know an even better straw mand and red herring (you can do both simultaneously.. remarkable), IS TO USE THE RATE FOR 1,000 GENERATIONS IN RADIATED FRUIT FLYS.. THTA'S MUCH HIGHER.
Not one of your examples is apples to apples .. pitiful.
All my ref’s were based on observations of human DNA, so I have been comparing ”apples to apples’ . unless you don’t really know what that means .
Where did irradiated fruit flies come up in my words? Talk about apples with apples .
You do raise an interesting point here though; many organisms have a naturally occurring mutation rate that is substantially higher than in humans. How do you account for those? Or do you believe that people have been arguing over human evolution only, these past 150 years.
You know, I really wouldn’t have that much of a problem with the figure you’ve supplied had DNA replication and repair occurred solely in isolation . They Do Not.
Cells are not closed systems; substances enter and leave all the time, some of which are responsible for mutagenesis. Even substances produced by cells themselves can cause mutations. As such any practical mutation rate is a function of both the causation of mutation (whether extrinsic or intrinsic) and the adequacy of repair mechanisms (which themselves often result in the fixation of a mutation). Organisms live in the real world, not in test tubes.
It is now known that mutation rate differs depending not only on location in the genome, but also on the gene itself. The mutation rates of certain genes, for
point mutations, can reach levels of 10E-5, rivaling even STR mutation rate.
You see, EP, there’s a lot more to mutation than a single number. If you actually knew anything about genetics . no, make that biology . you would realize this.
When one comes down to it, if mutations really were that rare, genetic disease would also be a rarity. Yet, do you know that there are more people living, and dying, of genetic disorders, than there are people living and dying of AIDS. Still, barring those, living and dying, of cancer.
Maybe one day, when you’re not blinded by your own ego, you might actually acknowledge that you live in the real world.
"The good Christian should beware the mathematician and all those who make empty prophecies. The danger already exists that the mathematicians have made a covenant with the devil to darken the spirit and to confine man in the bonds of hell." - St. Augustine
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