There are probably about 100 different philosophy positions that touch on what science would say about our physical world.
Specifically, the metaphysical world.
Neuroscience is a pretty materialistic profession. It commonly will show that our memories are made up of biological matter. Roger Penrose and Stuart Hammer off have attempted to find a non materialistic interpretation of our brain and consciousness, but an underground (literally subterranean) experiment, in Italy, did not back up the physical description of the theory.
LSD experiments are ongoing, and some physicists are always claiming to have made an LSD breakthrough, that challenges materialism.
Generally, just about nothing has truly challenged materialism, successfully.
UFOs - to the extent there has been "observations" by us, of them - seem to offer potential evidence that our physical laws need a better understanding, and some interpretations of UFOs involved interdimensional interpretations.
(John Brennan or James Clapper said UFOs seem to be interdimensional)
Materialism is the most relevant philosophy to a spiritual species, which humans seem to be.
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