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Author Topic:   Under Pressure, Does Evolution Evolve?
RAZD
Member (Idle past 1435 days)
Posts: 20714
From: the other end of the sidewalk
Joined: 03-14-2004


Message 3 of 7 (719114)
02-11-2014 2:10 PM
Reply to: Message 2 by Taq
02-11-2014 1:35 PM


Increasing the random mutation rate still produces random mutations. I see this mistake made by the press and scientists alike. The randomness of mutations has to do with their relation to fitness, not time, genomic loci, or rate.
Several different mechanism have been found iirc that reduce the error correction\counteraction, allowing more mutations that would otherwise be constricted.
Is it possible that some of these mechanisms affect some sections of the DNA more\less than others (are some sections more highly conserved)?

we are limited in our ability to understand
by our ability to understand
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This message is a reply to:
 Message 2 by Taq, posted 02-11-2014 1:35 PM Taq has replied

Replies to this message:
 Message 4 by Taq, posted 02-11-2014 3:16 PM RAZD has replied

  
RAZD
Member (Idle past 1435 days)
Posts: 20714
From: the other end of the sidewalk
Joined: 03-14-2004


Message 5 of 7 (719122)
02-11-2014 3:37 PM
Reply to: Message 4 by Taq
02-11-2014 3:16 PM


There is no doubt that some areas of a genome will experience higher mutation rates than others. ...
Would you say that the areas that are more highly conserved would be ones where mutations are more likely to be lethal?

we are limited in our ability to understand
by our ability to understand
Rebel American Zen Deist
... to learn ... to think ... to live ... to laugh ...
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This message is a reply to:
 Message 4 by Taq, posted 02-11-2014 3:16 PM Taq has replied

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 Message 6 by Taq, posted 02-11-2014 4:22 PM RAZD has replied

  
RAZD
Member (Idle past 1435 days)
Posts: 20714
From: the other end of the sidewalk
Joined: 03-14-2004


Message 7 of 7 (719137)
02-11-2014 6:03 PM
Reply to: Message 6 by Taq
02-11-2014 4:22 PM


On average, yes. ...
So - on average - the increase in mutation rate would be skewed slightly to less lethally deleterious mutations, but the rest is wide open random?
On average then, it could be argued that there is slightly increased beneficial\neutral mutations in proportion to total mutations?
Not by knowing what would be beneficial\neutral, but by knowing what is lethally deleterious and reducing those?
Edited by RAZD, : .

we are limited in our ability to understand
by our ability to understand
Rebel American Zen Deist
... to learn ... to think ... to live ... to laugh ...
to share.


Join the effort to solve medical problems, AIDS/HIV, Cancer and more with Team EvC! (click)

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