IMHO, this really isn't in any way the "death knell" for ID in any way whatsoever. ID proponents don't claim that the occurrence of 4 mutations is extremely improbable. The real issue here is whether all four mutations only offered a selective advantage once all four mutations had occurred. If this was the case, then this would be quite a difficulty for the ID folks. But sequence analysis doesn't show in any way that each mutation was in itself non-adaptive. Which means it's not a problem at all for ID.
However, it is true that removing one part of the system destroys its function (using OmpF). Now the IDists' arguments about IC rest on the assumption that in such a case each of the parts separately is useless, and so the system cannot have been assembled a bit at a time by natural selection causing the parts to accumulate, because natural selection would not have acted on the parts.
The fact that each mutation
was adaptive is just what shows that they were wrong. The evolutionist case against Behe is not that such combinations of mutations can with reasonable probability arise all at once by chance, but that the series of changes leading to the final system can be produced by a series of steps each of which is adaptive even though it does not produce the final system having the final function. This experiment shows a case of that happening.
So this part of your post seems completely ass-backwards:
The real issue here is whether all four mutations only offered a selective advantage once all four mutations had occurred. If this was the case, then this would be quite a difficulty for the ID folks.
No, that would have been a problem for the evolutionists. They would be left with no known mechanism to explain why this pathway is followed, and followed repeatedly, in reruns of the experiment, since this could not be explained by chance (too many long shots coming up) or by the cumulative effect of natural selection (which would not, by hypothesis, act).
Meanwhile
Behe could have gone around saying that this was the first observed instance of his invisible designer magically tampering with genomes to produce an IC system.
The actual observation is therefore a blow against ID precisely
because the system evolved
by completely normal Darwinian processes, as evolutionists claim that such systems evolve.
Edited by Dr Adequate, : No reason given.