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Wouldn't the high rate of diabetes, heart disease, cancer be considered harmful mutations in the gene pool?
Whether the mutations involved are harmful in the evolutionary sense depends on how much they affect the ability to reproduce. All of those diseases mostly strike later in life, and don't have much evolutionary effect. The associated mutations are probably mildly deleterious overall in our current environment. (When food was more scarce and people seldom lived to old age, some of the same genetic variants were probably beneficial, e.g. variants that predispose toward diabetes may also enable one to handle lack of calories better.)
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These are certainly on the rise and are listed on most individuals past medical and family history forms when they come into the doctor's office as a new patient.
The diseases are on the rise, but that doesn't mean the genetic variants that put one at risk are on the rise. People are getting diabetes more often and at younger ages not because a deleterious mutation is spreading in the population, but because they're eating more and exercising less.
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Mixed race offspring is very common these days and I see that eventually with all of these genes being mixed together that the global population will consist of human mutts some day.
We've always consisted of human mutts: there has always been gene flow between populations, and the populations were never that different to start with. But yes, what regional differences there have been are breaking down. I don't know what this has to do with deleterious mutations, though.