Unlikely, but there have been some creatures known to elude human detection for long periods of time. There was a time when scientists declared that they had, with complete confidence, found all four-legged animals in the world. Yet in the early 1990's a new species of deer was discovered in Vietnam that was unknown to science.
I know the seas are still teeming with yet discovered creatures. Not long ago the idea of "giant squid" was little more than myth until scientifically verified.
There's always a possibility, but some creatures are more remote in possibility than others.
When the difficulty of science to declare an active species come up, it reminds me of the game-cam motion detector photos I have seen of
Mountain Lions in Missouri[ (that's the first Google hit).
As far as I know, the conservation office still holds the position of there not being a breeding population in MO, that being the "scientific" explanation.
I've seen that there's enough of them out there to be caught on random game-cams, which I think suggest a breeding population.
It kinda reminds me of the "Immaterial Evidence" thread where I should probably be doubting that the photo I saw was real because that's a more likely explanation than there actually being something out there that hasn't been repeated, replicated, and verified by the almighty science. Which is the impression I'm getting from the skeptics in that debate that the argument ultimately comes down to.
Which I think I'll link to now.