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Author Topic:   The Human Genome and Evolution
GDR
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Posts: 6202
From: Sidney, BC, Canada
Joined: 05-22-2005
Member Rating: 2.3


Message 1 of 106 (219456)
06-24-2005 10:34 PM


As a disclaimer I have no background in either genetics or biology, so I am not trying to make a point. I'm just looking for information. I'm a participant in the National Geographic "Genographic" project. Is it possible that through projects such as this or others that it will be possible to trace back human evolution to pre modern man or further.
I guess what I'm really asking is, what is the connection, if any, between genetics and evolution, and will genetics ever be able to conclusively prove or disprove macroevolution.

Replies to this message:
 Message 3 by Tranquility Base, posted 06-27-2005 8:00 AM GDR has replied

  
GDR
Member
Posts: 6202
From: Sidney, BC, Canada
Joined: 05-22-2005
Member Rating: 2.3


Message 4 of 106 (220064)
06-27-2005 2:21 PM
Reply to: Message 3 by Tranquility Base
06-27-2005 8:00 AM


Tranquility Base writes:
As we step from one genome to another we find numerous additions of gene types that bare no resemblance to sequences whatsoever in the supposed anscestral genome despite the near identical 'house keeping' genes. Creationists, like myself prefer to point out these differences which we think demonstrate the handiwork of God. Evolutionists instead dwell on the core similarities between the genomes.
It seems to me, just from a common sense point of view, that if evolution were just happening by natural selection that the genetic changes that occur in macroevolution would change incrementally one or two changes, of whatever type, at a time.
If however there is divine intervention involved in the process it seems to me that it is more likely that several changes would occur simultaneously to bring about a new species.
Does this make sense, and have biologists been able to sort out the rate of change that occurred in our evolutionary history, and if not, is there progress being made in this area?
Thanks

This message is a reply to:
 Message 3 by Tranquility Base, posted 06-27-2005 8:00 AM Tranquility Base has replied

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 Message 5 by Tranquility Base, posted 06-27-2005 9:08 PM GDR has replied

  
GDR
Member
Posts: 6202
From: Sidney, BC, Canada
Joined: 05-22-2005
Member Rating: 2.3


Message 6 of 106 (220267)
06-27-2005 10:31 PM
Reply to: Message 5 by Tranquility Base
06-27-2005 9:08 PM


Tranquility Base writes:
But it will rest on the *assumption* of macroevolution.
Thanks a lot that helps a lot.
Just so I understand what you mean by this; is it still considered macroevolution whether there is divine intervention or not. The term evolution seems to mean different things to different people.
As far as I understand it the term evolution,(specifically macro evolution), still holds whether there is no divine intervention at all, if it is set in motion by divine intervention and then left to develop on its own, or whether it is divinely adjusted during the process. Would you agree?

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 Message 5 by Tranquility Base, posted 06-27-2005 9:08 PM Tranquility Base has replied

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 Message 7 by Tranquility Base, posted 06-27-2005 11:13 PM GDR has replied

  
GDR
Member
Posts: 6202
From: Sidney, BC, Canada
Joined: 05-22-2005
Member Rating: 2.3


Message 8 of 106 (220302)
06-28-2005 1:03 AM
Reply to: Message 7 by Tranquility Base
06-27-2005 11:13 PM


Thanks. In the trials that are being conducted would it be conceivable then that human DNA could actually be traced back to a prehuman species? In simple terms what are the limits or do we know?

This message is a reply to:
 Message 7 by Tranquility Base, posted 06-27-2005 11:13 PM Tranquility Base has replied

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 Message 9 by Tranquility Base, posted 06-28-2005 1:12 AM GDR has not replied
 Message 10 by mick, posted 06-28-2005 4:41 PM GDR has replied

  
GDR
Member
Posts: 6202
From: Sidney, BC, Canada
Joined: 05-22-2005
Member Rating: 2.3


Message 15 of 106 (220598)
06-28-2005 11:27 PM
Reply to: Message 10 by mick
06-28-2005 4:41 PM


mick writes:
You can only trace human DNA back to a nonhuman species by including nonhuman species in the dataset - which of course has been done, but not by the genographic project.
Thanks mick
When you say it has been done can you outline the result in the simplest of terms?

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 Message 10 by mick, posted 06-28-2005 4:41 PM mick has not replied

  
GDR
Member
Posts: 6202
From: Sidney, BC, Canada
Joined: 05-22-2005
Member Rating: 2.3


Message 50 of 106 (222602)
07-08-2005 2:00 PM
Reply to: Message 49 by EZscience
07-08-2005 11:37 AM


Re: Human 'kinds' and others
EZScience writes:
OK. But what is this invisible boundary that delimits the human 'kind'.
For example, to persue your argument from an evolutionary perspective, we might use chimps as an outgroup and test sequence homology between humans chimps and Neanderthals and find the latter closer to humans than the former. So we have:
Humans __________________________(common ancestor)
Neanderthals_______/..................../
Chimps______________________/
Hi EZ (If I can call you that for short )
My understanding is that evolution has us evolving from apes and that chimps are closest to humans in their DNA composition. By your diagram you seem to be suggesting that humans, chimps and neanderthals separately evolved from a common ancestor.
Are you just using this for purpose of illustration or is this generally considered a possibility?
With no background in this at all I try to stay away from any of the technical discussions except to try and learn what I can, but I'm very curious about the basis for your diagram. Thanks

This message is a reply to:
 Message 49 by EZscience, posted 07-08-2005 11:37 AM EZscience has replied

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GDR
Member
Posts: 6202
From: Sidney, BC, Canada
Joined: 05-22-2005
Member Rating: 2.3


Message 75 of 106 (223207)
07-11-2005 6:15 PM
Reply to: Message 74 by EZscience
07-11-2005 4:21 PM


Re: Human 'kinds' and others
EZScience writes:
I have given up trying to 'convince' creationists. They will see god in a genome as fast as a Latin American will see the virgin Mary in a taco. I will settle for demonstrating they have no workable scientific mechanisms or testable theories, nor can any functional insights be derived from their musings.
I'm not sure that is fair. It seems to me that science can only tell us how we evolved; it cannot tell us whether or not there is any metaphysical intervention or not. Isn't it just as much a matter of faith to say that there is only random selection, with no divine intervention, as it is to say that evolution is guided by a metaphysical intelligence?
There is no empirical evidence for either conclusion, so our opinions on this are formed from philosophy, or theology, but not science.
This message has been edited by GDR, 07-11-2005 03:16 PM

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 Message 74 by EZscience, posted 07-11-2005 4:21 PM EZscience has replied

Replies to this message:
 Message 76 by crashfrog, posted 07-11-2005 7:03 PM GDR has replied
 Message 85 by EZscience, posted 07-12-2005 6:40 AM GDR has replied

  
GDR
Member
Posts: 6202
From: Sidney, BC, Canada
Joined: 05-22-2005
Member Rating: 2.3


Message 77 of 106 (223225)
07-11-2005 7:13 PM
Reply to: Message 76 by crashfrog
07-11-2005 7:03 PM


crash writes:
Where's the faith? That sort of second-guessing hedging-your-bets seems like the exact antipode of faith to me.
You always come back to what is basically the old opiate of the masses thing. I would be a Christian with or without the concept of eternal life because I believe that it's the truth. I'm interested in what Christianity means to me in this life.
I love what science has done but there is more to this world than what can be proven scientifically.

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 Message 76 by crashfrog, posted 07-11-2005 7:03 PM crashfrog has replied

Replies to this message:
 Message 99 by crashfrog, posted 07-14-2005 6:29 PM GDR has replied

  
GDR
Member
Posts: 6202
From: Sidney, BC, Canada
Joined: 05-22-2005
Member Rating: 2.3


Message 86 of 106 (223361)
07-12-2005 10:49 AM
Reply to: Message 85 by EZscience
07-12-2005 6:40 AM


Re: Human 'kinds' and others
EZScience writes:
True enough. Science does not address final origins. But it works very well to explain the 'how' without the need to invoke any metaphyscial intervention, so why postulate what isn't needed?
There are two great questions in life. How did we get here and why are we here. The how we got here is fascinating but the why is central to our whole being.
To go back to the OP though, it was mentioned somewhere in the thread that the tracing back of our DNA will not be able to give evidence for, or against for that matter, macroevolution.
Is it possible in lay terms to say why that is so? It seems to me that if macroevolution occurs incrementally, one mutation at a time, then there would be a DNA trail to follow. If however, there were multiple changes simultaneously then the DNA trail would stop at this point. (In asking this question I'm only trying to apply logic to a subject I know nothing about technically.)
This message has been edited by GDR, 07-12-2005 07:50 AM

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 Message 85 by EZscience, posted 07-12-2005 6:40 AM EZscience has replied

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GDR
Member
Posts: 6202
From: Sidney, BC, Canada
Joined: 05-22-2005
Member Rating: 2.3


Message 100 of 106 (223818)
07-14-2005 6:48 PM
Reply to: Message 99 by crashfrog
07-14-2005 6:29 PM


crashfrog post 75 writes:
I dunno. It seems like the exact opposite of faith to me to say "if there's no evidence for it, it probably didn't happen, but maybe we'll learn something in the future and find out we were wrong."
It seems to me that it is just as true to say that there is no proof that anything happened simply by natural processes. Science can only look at what happened and is unable to come to any conclusion whether there is any metaphysical interference or not. We have to take it on faith either way. Science can only be agnostic and anything beyond that requires faith in something that has been unproven.
crashfrog writes:
So many of you say, but I've never seen anything like that. If you believe this to be true then that's something you take on faith. I'm not prepared to do that.
I would imagine that there are many who have studied philosophy who would disagree with you.

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 Message 99 by crashfrog, posted 07-14-2005 6:29 PM crashfrog has not replied

Replies to this message:
 Message 101 by Wounded King, posted 07-14-2005 7:04 PM GDR has replied

  
GDR
Member
Posts: 6202
From: Sidney, BC, Canada
Joined: 05-22-2005
Member Rating: 2.3


Message 102 of 106 (223825)
07-14-2005 7:46 PM
Reply to: Message 101 by Wounded King
07-14-2005 7:04 PM


Thanks WK. You are right of course. I do let myself get sucked in. Back to the OP. I think that the clearest answer to my question was given early on by mick.
mick writes:
If you gather genetic sequences from a number of individuals, you can infer the evolutionary history of those individuals back until you reach their most recent common ancestor. When genetic sequences are gathered only from members of the human species, the most recent common ancestor of the sampled individuals will by definition also be a human being. You can only trace human DNA back to a nonhuman species by including nonhuman species in the dataset - which of course has been done, but not by the genographic project.
I believe the genographic project is more concerned with population processes within the species over historical time - for example the inference of migration patterns and demographic parameters.
It sounds as if genetic research will not be able to trace human lineage beyond our common ancestor and his comment on the Genographic project is correct as well.

This message is a reply to:
 Message 101 by Wounded King, posted 07-14-2005 7:04 PM Wounded King has replied

Replies to this message:
 Message 103 by Wounded King, posted 07-15-2005 2:18 AM GDR has replied

  
GDR
Member
Posts: 6202
From: Sidney, BC, Canada
Joined: 05-22-2005
Member Rating: 2.3


Message 104 of 106 (223914)
07-15-2005 11:10 AM
Reply to: Message 103 by Wounded King
07-15-2005 2:18 AM


Wounded King writes:
I'm not sure why you would conclude that. We certainly might not be able to trace an unbroken lineage but there is a pretty substantial body of evidence suggesting that humans and chimps shared a common ancestor 5-6 million years ago.
Wihtout a great deal of luck in finding preserved specimens and continued refinement of our usage of ancient DNA I doubt that we will ever actually get DNA from whtever species was that common ancestor. We may try to reconstruct an ancestral genome but usually these are based on a larger number of species than 2, maybe an ancestral genome for the great apes could be reconstructed.
I guess the real issue is how detailed you want your lineage to be.
My genographic history has me with a M168 marker that takes me back to a common ancestor about 60,000 years ago. As I understand it everyone goes back to a common male ancestor out of Africa about 70,000 years ago.
Are you saying that if they did a study of the genome of a group of great apes they could then use that study to trace our DNA back even further to a common ancestor of both species?
As I said at the beginning, I was wondering if through the study of genetic history if we would be able to provide conclusive evidence for how evolution occurred. I do understand that through genetics they have proven that we aren't related to Neanderthal man.

This message is a reply to:
 Message 103 by Wounded King, posted 07-15-2005 2:18 AM Wounded King has replied

Replies to this message:
 Message 105 by Wounded King, posted 07-15-2005 11:52 AM GDR has replied

  
GDR
Member
Posts: 6202
From: Sidney, BC, Canada
Joined: 05-22-2005
Member Rating: 2.3


Message 106 of 106 (223935)
07-15-2005 1:49 PM
Reply to: Message 105 by Wounded King
07-15-2005 11:52 AM


Thanks a lot. That's a very interesting site and although the technical part is so far over my head that the Hubble telescope couldn't find it, the site does pretty much answer my question, (along with your response). It has to be an exciting time to be a scientist in any field. I envy you guys that are.
So, I think the answer is that in the future there is a good possibility that the study of genetics will be able to trace our ancestory through a period of macroevolution.
In your opinion it sounds like these studies could be fairly conclusive in confirming evolution eventually, but could they prove a negative as well if it were to turn out that macroevolution does not happen?

This message is a reply to:
 Message 105 by Wounded King, posted 07-15-2005 11:52 AM Wounded King has not replied

  
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