Is it harder to change "species" or does it just require more time?
That is actually a very good question. For one reason, if the species line is crossed then the much larger changes between higher taxa isn't so hard given enough time.
However, if speciation hasn't happened then (and there is a mountain or research on this) there are evolutionary forces that would tend to homogenize the population involved.
In other words to get a speciation event (it is argued) requires something to separate a population. The typical example is geography; they have to be kept separate.
However, lots of things can cause this separation. If birds sing a different song they may not mate. Even though they would produce perfectly viable offspring if they did.
I don't remember details but there is some parasite of some mmm fly? I think. That changes the reproduction in some way (good isn't this, fuzzy as hell) that means that an indivdual infected with the parasite can only successfully breed with an other infected individual.
This can separate the population into two and allow full speciation to take place.
There are cases of "instant" speciation where a plants get a chromasomal mutation that means they can not longer reproduce with the other "kind". This can happen in one step.
And so on and so forth.
So let's back up.
"Micro" happens all the time, every individual is different from others. They have some mutations. However, if there is no speciation event or some kind of separation the mutations will spread through the population and it will stay somewhat uniform.
That, by the way, doesn't mean that these changes can't gradually pile up so that an individual of the population that is around 10,000 generations from now would still be the same species as the starting population.
If however, there is something to separate the population into two different ones for awhile then speciation, it seems, can happen pretty quickly.
Once you have separate species the changes can not longer be smoothed out between them and over a long enough time very, very large changes happen. Obviously something as large as reptile to mammal doesn't happen in only 1,000's of generations.