Anyways, given this example...I'm curious if high levels of physical exertion throughout a lifetime from generation to generation could potentially mutate genetics.
It seems to me you aren't clear on your terms. Continuous consumption of alcohol in Europeans did
not mutate their genes; it selected for people with a higher alcohol tolerance - presumably because they were more able to function while drinking, and less likely to consume other, less safe, liquids thus increasing both their likelyhood of surviving to adulthood and their ability to support more children.
Anyways, given this example...I'm curious if high levels of physical exertion throughout a lifetime from generation to generation could potentially mutate genetics.
In short, no. Unless that physical exertion was directed towards a goal that increased (at least one of) their likelyhood of living to reproductive age, their ability to attract mates and their ability to support children (for example, if they were hunted by fierce predators faster runners could be more likely to survive, women could prefer more athletic men or among active hunters there could be a selection pressure for higher endurance and faster runners, respectively).