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Author Topic:   Age and Down Syndrome?
New Cat's Eye
Inactive Member


Message 46 of 76 (714086)
12-19-2013 4:18 PM
Reply to: Message 45 by PlanManStan
12-19-2013 3:37 PM


"Look it up" isn't synonymous with "Google it".
It is in my world.
And is it?
Use the quote function already, is what what?
Is "normal" defined as what the gene did before the mutation? Isn't that gene, then, abnormal based on what it is a mutation of?
Sure, but as a gene gets fixated there shouldn't be a problem with calling it normal. Although, normalcy is kind of a fluffy concept anyways.
It isn't what it was before, but is that necessarily "damage"?
Not necessarily, but the word "damage" can work. I can see unnecessary implications and that the usage is sloppy, but I don't think its totally unwarranted.
I understand where you are coming from and don't doubt your knowledge, I'm just saying that damage is a poor word to use, because it implies certain things, like tampering. The way "damage" is usually used, it implies someone tampered with something and caused it harm.
I don't see that implication at all. The sun damages our skin, for instance.

This message is a reply to:
 Message 45 by PlanManStan, posted 12-19-2013 3:37 PM PlanManStan has replied

Replies to this message:
 Message 48 by PlanManStan, posted 12-19-2013 4:57 PM New Cat's Eye has replied

  
NoNukes
Inactive Member


Message 47 of 76 (714088)
12-19-2013 4:41 PM
Reply to: Message 43 by PlanManStan
12-19-2013 1:13 PM


For the last time, my entire position is just that damage is not a good word to use in this context. Damage is simply not the correct terminology! That's all I'm saying, for God's sake!
And what everyone else is telling you is that you are wrong, and that damage is the correct, and commonly applied terminology. That the terminology is in common use by everybody but you is readily apparent from the results of a few internet searches using 'genetic damage'.
Further, making up some other name to call detrimental mutations that produce disfunction does not even address Faith's accusation anyway.
Just because Faith is wrong does not mean that every silly counter argument is legit.

Under a government which imprisons any unjustly, the true place for a just man is also in prison. Thoreau: Civil Disobedience (1846)
I believe that a scientist looking at nonscientific problems is just as dumb as the next guy.
Richard P. Feynman
If there is no struggle, there is no progress. Those who profess to favor freedom, and deprecate agitation, are men who want crops without plowing up the ground, they want rain without thunder and lightning. Frederick Douglass

This message is a reply to:
 Message 43 by PlanManStan, posted 12-19-2013 1:13 PM PlanManStan has replied

Replies to this message:
 Message 49 by PlanManStan, posted 12-19-2013 4:59 PM NoNukes has replied

  
PlanManStan
Member (Idle past 3710 days)
Posts: 73
Joined: 12-12-2013


Message 48 of 76 (714093)
12-19-2013 4:57 PM
Reply to: Message 46 by New Cat's Eye
12-19-2013 4:18 PM


I have no idea how to use the quote function. No one has told me. Remember, this is my 6th day on this site.
What do you mean by "when a gene gets fixated"?
I see your point, and there's nothing to argue about, because we are agreeing here that damage is a sloppy term

This message is a reply to:
 Message 46 by New Cat's Eye, posted 12-19-2013 4:18 PM New Cat's Eye has replied

Replies to this message:
 Message 50 by New Cat's Eye, posted 12-19-2013 5:11 PM PlanManStan has not replied

  
PlanManStan
Member (Idle past 3710 days)
Posts: 73
Joined: 12-12-2013


Message 49 of 76 (714094)
12-19-2013 4:59 PM
Reply to: Message 47 by NoNukes
12-19-2013 4:41 PM


Okay, let's say there's a gene for, I don't know, having your legs be 45 inches. Now, the gene mutates and legs are only 43 inches. Is that damage? No, it is change. All I'm saying is that change is a better term here, if we want to be nit-picky. This is hardly about Faith anymore, is he even here still?

This message is a reply to:
 Message 47 by NoNukes, posted 12-19-2013 4:41 PM NoNukes has replied

Replies to this message:
 Message 51 by NoNukes, posted 12-20-2013 7:58 AM PlanManStan has replied

  
New Cat's Eye
Inactive Member


Message 50 of 76 (714096)
12-19-2013 5:11 PM
Reply to: Message 48 by PlanManStan
12-19-2013 4:57 PM


I have no idea how to use the quote function. No one has told me. Remember, this is my 6th day on this site.
If you type into the text box: [qs]shaded quotes are easy[/qs], then it will become:
shaded quotes are easy
If you type into the text box: [quote]regular quotes are also easy[/quote] then it will become:
quote:
regular quotes are also easy
I prefer shaded quotes ("qs" means "Quote Shaded") for when quoting from the message you're replying to and regular quotes for when you are quoting from outside of that message.
After you hit "Reply" next to the text box you'll see this:
dBCodes On (help)
That help link will take you to a page outlining the kinds of coding you can do.
Also, at the bottom right corner of every message is a "Peek" button. That will show you exactly what the person entered into the text box. So if you see something awesome that you want to do, take a Peek.
What do you mean by "when a gene gets fixated"?
wiki on fixation
I see your point, and there's nothing to argue about, because we are agreeing here that damage is a sloppy term
Fair enough. On the other hand, its a completely accurate term used by molecular biologists:
quote:
The process by which normal cells become progressively transformed to malignancy is now known to require the sequential acquisition of mutations which arise as a consequence of damage to the genome. This damage can be the result of endogenous processes such as errors in replication of DNA, the intrinsic chemical instability of certain DNA bases or from attack by free radicals generated during metabolism. DNA damage can also result from interactions with exogenous agents such as ionizing radiation, UV radiation and chemical carcinogens. Cells have evolved means to repair such damage, but for various reasons errors occur and permanent changes in the genome, mutations, are introduced.source
bold added for emphasis

This message is a reply to:
 Message 48 by PlanManStan, posted 12-19-2013 4:57 PM PlanManStan has not replied

  
NoNukes
Inactive Member


Message 51 of 76 (714144)
12-20-2013 7:58 AM
Reply to: Message 49 by PlanManStan
12-19-2013 4:59 PM


Okay, let's say there's a gene for, I don't know, having your legs be 45 inches. Now, the gene mutates and legs are only 43 inches. Is that damage?
No, I would not call that damage, but again contrived examples do not prove anything because I don't claim that all mutations are damage.
Let's imagine a mutation that produces an inheritable change where the organism has no legs at all. Or where the animal is born with a spinal cord that won't transmit signals to the legs. I would call that genetic damage and so would everyone else except you.

Under a government which imprisons any unjustly, the true place for a just man is also in prison. Thoreau: Civil Disobedience (1846)
I believe that a scientist looking at nonscientific problems is just as dumb as the next guy.
Richard P. Feynman
If there is no struggle, there is no progress. Those who profess to favor freedom, and deprecate agitation, are men who want crops without plowing up the ground, they want rain without thunder and lightning. Frederick Douglass

This message is a reply to:
 Message 49 by PlanManStan, posted 12-19-2013 4:59 PM PlanManStan has replied

Replies to this message:
 Message 52 by PlanManStan, posted 12-20-2013 9:48 AM NoNukes has replied

  
PlanManStan
Member (Idle past 3710 days)
Posts: 73
Joined: 12-12-2013


Message 52 of 76 (714152)
12-20-2013 9:48 AM
Reply to: Message 51 by NoNukes
12-20-2013 7:58 AM


So because everyone else would call it damage, that makes it more correct?
Let's imagine a mutation that produces an inheritable change where the organism has no legs at all. Or where the animal is born with a spinal cord that won't transmit signals to the legs.
I would definitely call that detrimental, I just wouldn't say the word damage.

This message is a reply to:
 Message 51 by NoNukes, posted 12-20-2013 7:58 AM NoNukes has replied

Replies to this message:
 Message 53 by 1.61803, posted 12-20-2013 11:02 AM PlanManStan has not replied
 Message 54 by NoNukes, posted 12-20-2013 11:49 AM PlanManStan has replied

  
1.61803
Member (Idle past 1526 days)
Posts: 2928
From: Lone Star State USA
Joined: 02-19-2004


Message 53 of 76 (714162)
12-20-2013 11:02 AM
Reply to: Message 52 by PlanManStan
12-20-2013 9:48 AM


PlanManStan writes:
I would definitely call that detrimental, I just wouldn't say the word damage.
What criteria do you have for the word damage to be used?
MERRIAM WEBSTERS:Detrimental Definition & Meaning - Merriam-Webster
detrimental adjective \ˌde-trə-ˈmen-təl\ : causing damage or injury

"You were not there for the beginning. You will not be there for the end. Your knowledge of what is going on can only be superficial and relative" William S. Burroughs

This message is a reply to:
 Message 52 by PlanManStan, posted 12-20-2013 9:48 AM PlanManStan has not replied

  
NoNukes
Inactive Member


Message 54 of 76 (714171)
12-20-2013 11:49 AM
Reply to: Message 52 by PlanManStan
12-20-2013 9:48 AM


I would definitely call that detrimental, I just wouldn't say the word damage.
Right. Which means that when there is a discussion about genetic damage, you will pretend to have an issue while the rest of us discuss the topic using correct terminology.

Under a government which imprisons any unjustly, the true place for a just man is also in prison. Thoreau: Civil Disobedience (1846)
I believe that a scientist looking at nonscientific problems is just as dumb as the next guy.
Richard P. Feynman
If there is no struggle, there is no progress. Those who profess to favor freedom, and deprecate agitation, are men who want crops without plowing up the ground, they want rain without thunder and lightning. Frederick Douglass

This message is a reply to:
 Message 52 by PlanManStan, posted 12-20-2013 9:48 AM PlanManStan has replied

Replies to this message:
 Message 55 by PlanManStan, posted 12-20-2013 11:59 AM NoNukes has not replied

  
PlanManStan
Member (Idle past 3710 days)
Posts: 73
Joined: 12-12-2013


Message 55 of 76 (714176)
12-20-2013 11:59 AM
Reply to: Message 54 by NoNukes
12-20-2013 11:49 AM


I'm not trying to, like, troll. I was making an argument for why using the word "damage" is not correct. Regardless of what the word actually means, it is how it is commonly used. For example, we use the word "peruse" to mean "skim over quickly" commonly, but it actually means to read something, usually quite thorough and careful way. Similarly, we use damage in a sense that it was tampered with by an outside force (like a small child, or a hurricane), even though it may mean something else. Do you see my point?

This message is a reply to:
 Message 54 by NoNukes, posted 12-20-2013 11:49 AM NoNukes has not replied

  
ringo
Member (Idle past 434 days)
Posts: 20940
From: frozen wasteland
Joined: 03-23-2005


Message 56 of 76 (714178)
12-20-2013 12:00 PM
Reply to: Message 39 by New Cat's Eye
12-19-2013 12:43 PM


Catholic Scientist writes:
If you damage the roof my car, but then it ends up going faster, I don't think there should be a problem with saying the roof was damaged.
I do have a problem with calling an improvement "damage". When a gene is changed we don't know if it's going to be an improvement or damage, so I think it's best to call it a "change".

This message is a reply to:
 Message 39 by New Cat's Eye, posted 12-19-2013 12:43 PM New Cat's Eye has not replied

Replies to this message:
 Message 58 by AZPaul3, posted 12-20-2013 5:59 PM ringo has seen this message but not replied

  
1.61803
Member (Idle past 1526 days)
Posts: 2928
From: Lone Star State USA
Joined: 02-19-2004


Message 57 of 76 (714198)
12-20-2013 12:54 PM


When I was in school, we used the word deleterious ,when describing damage or negative changes to genes. But I have no problem using the word damaged either.

"You were not there for the beginning. You will not be there for the end. Your knowledge of what is going on can only be superficial and relative" William S. Burroughs

  
AZPaul3
Member
Posts: 8536
From: Phoenix
Joined: 11-06-2006
Member Rating: 5.0


Message 58 of 76 (714234)
12-20-2013 5:59 PM
Reply to: Message 56 by ringo
12-20-2013 12:00 PM


Agreed. Damage has a negative connotation while the result of the change or mutation may not be negative at all. Though CS may be, in some small way, technically within bounds, the word damaged instead of changed or mutated does not give as accurate a reflection of what is taking place when discussing genetics. This may leave the mistaken impression (except if one is a creationist bent on misrepresentation) that the change, mutation, damage results in something less than what may accurately occur.

This message is a reply to:
 Message 56 by ringo, posted 12-20-2013 12:00 PM ringo has seen this message but not replied

Replies to this message:
 Message 59 by NoNukes, posted 12-20-2013 6:59 PM AZPaul3 has replied

  
NoNukes
Inactive Member


Message 59 of 76 (714239)
12-20-2013 6:59 PM
Reply to: Message 58 by AZPaul3
12-20-2013 5:59 PM


negative connotation
Of course damage is negative. That's why it is used to refer to deleterious mutations. What does deleterious mean?
Nothing untoward results from using the term damage in connection with mutations "causing damage or injury.
Here we have one person who claims that all mutations are damage and another who answers by saying no mutations cause damage. Both claims are wrong.

Under a government which imprisons any unjustly, the true place for a just man is also in prison. Thoreau: Civil Disobedience (1846)
I believe that a scientist looking at nonscientific problems is just as dumb as the next guy.
Richard P. Feynman
If there is no struggle, there is no progress. Those who profess to favor freedom, and deprecate agitation, are men who want crops without plowing up the ground, they want rain without thunder and lightning. Frederick Douglass

This message is a reply to:
 Message 58 by AZPaul3, posted 12-20-2013 5:59 PM AZPaul3 has replied

Replies to this message:
 Message 60 by PlanManStan, posted 12-20-2013 7:02 PM NoNukes has replied
 Message 62 by AZPaul3, posted 12-20-2013 7:34 PM NoNukes has replied

  
PlanManStan
Member (Idle past 3710 days)
Posts: 73
Joined: 12-12-2013


Message 60 of 76 (714240)
12-20-2013 7:02 PM
Reply to: Message 59 by NoNukes
12-20-2013 6:59 PM


Here we have one person who claims that all mutations are damage and another who answers by saying no mutations cause damage. Both claims are wrong.
Who said that, and when? Please, go on and quote it. As I have said, "damage" in its most common usage implies tampering, and as far as I know, there isn't some little man in your DNA tampering with your genetic information.

This message is a reply to:
 Message 59 by NoNukes, posted 12-20-2013 6:59 PM NoNukes has replied

Replies to this message:
 Message 61 by NoNukes, posted 12-20-2013 7:28 PM PlanManStan has replied

  
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