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Author | Topic: Quick Questions, Short Answers - No Debate | |||||||||||||||||||
Admin Director Posts: 13023 From: EvC Forum Joined: Member Rating: 1.9 |
Catholic Scientist writes: Weren't you talking about going to dBoard 3.0 sometime before? Did you decide on MySQL instead? dBoard 2.0, the current installed version, uses MySQL for the member database. dBoard 3.0 will use MySQL for the message database, too. I already have most of the software written and debugged, but I need a large block of free time (weeks) to complete it and then release it. Yes, the limit should be in the FAQ.
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Cold Foreign Object  Suspended Member (Idle past 3070 days) Posts: 3417 Joined: |
Whatever happened to Crashfrog?
Why is Jar banned? Ray
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Percy Member Posts: 22480 From: New Hampshire Joined: Member Rating: 4.8 |
Testing...
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Dr Adequate Member (Idle past 306 days) Posts: 16113 Joined: |
What happens when a ribosome translates mRNA lacking a stop codon?
Many thanks to anyone who can tell me.
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Wounded King Member Posts: 4149 From: Cincinnati, Ohio, USA Joined: |
Dr.A writes: What Happens When A Ribosome Translates mRNA Lacking A Stop Codon? Such transcripts are called 'nonstop' and they are targeted for degradation when they cause the ribosome to hang in the absence of a termination codon. The mechanisms of degradation are different in prokaryotes and eukaryotes. TTFN, WK
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teen4christ Member (Idle past 5821 days) Posts: 238 Joined: |
I'd imagine it's like having a program with an infinite loop.
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Dr Adequate Member (Idle past 306 days) Posts: 16113 Joined: |
Thanks. That seems to conflict with the idea I'd picked up that frameshift mutations are less harmful near the end of the gene. 'Cos the nearer the end of the gene they are, the more likely it is that the frameshift will make the thing nonstop.
I am also now more curious than ever to know how amber suppressor strains get away with it. Edited by Dr Adequate, : No reason given.
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Dr Adequate Member (Idle past 306 days) Posts: 16113 Joined: |
I'd imagine it's like having a program with an infinite loop. No, not really. The bit of mRNA may not have a stop codon, but it still has an end. If there's no stop codon, the ribosome would keep on going down the mRNA stringing amino acids together until it reached the 3' end of the mRNA. What was puzzling me was what would happen then.
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Wounded King Member Posts: 4149 From: Cincinnati, Ohio, USA Joined: |
Thanks. That seems to conflict with the idea I'd picked up that frameshift mutations are less harmful near the end of the gene. 'Cos the nearer the end of the gene they are, the more likely it is that the frameshift will make the thing nonstop. Well it wouldn't necessarily make it much more likely to have a 'nonstop' transcript in any case as there is still a high likelihood there will be a new stop site introduced by the frameshift either in the remaining coding sequence or in the 3' untranslated region. TTFN, WK
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Dr Adequate Member (Idle past 306 days) Posts: 16113 Joined: |
True; but nonetheless the closer the frameshift is to the end, the less likely it is to produce another stop codon.
I just realised that I don't know how big the bit after the stop codon is, typically ... if it tends to be large and varied, I guess that nonstop mRNA wouldn't occur that often no matter where the frameshift takes place.
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BMG Member (Idle past 231 days) Posts: 357 From: Southwestern U.S. Joined: |
Please do not reply here. This has been reposted as a new thread: Global Cooling?. --Admin
Someone posted this article I have below as support that the global warming phenomenon is a "hoax", and that the Earth is likely going to cool. http://ibdeditorial.com/IBDArticles.aspx?id=287279412587175 I have yet to refute this argument. I am researching now the sources that are used in the article, and the effects of the solar cycle on the Earth's climate, but I could use the help of the EVC team. Here are some quotes from the article itself: "[Kenneth] Tapping reports no change in the sun's magnetic field so far this cycle and warns that if the sun remains quiet for another year or two, it may indicate a repeat of that period of drastic cooling of the Earth, bringing massive snowfall and severe weather to the Northern Hemisphere". And one more, from the Hoover Institution, "The effects of solar activity and volcanoes are impossible to miss. Temperatures fluctuated exactly as expected, and the pattern was so clear that, statistically, the odds of the correlation existing by chance were one in 100," according to Hoover fellow Bruce Berkowitz. " One more, from the Hoover Institution, "The study says that 'try as we might, we simply could not find any relationship between industrial activity, energy consumption and changes in global temperatures'". Edited by Admin, : Add comment about new thread.
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AZPaul3 Member Posts: 8536 From: Phoenix Joined: Member Rating: 5.0 |
What does IIRC mean as used on this forum?
Thanks much in advance.
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Chiroptera Inactive Member |
If I recall correctly.
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AZPaul3 Member Posts: 8536 From: Phoenix Joined: Member Rating: 5.0 |
Thank you.
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Taz Member (Idle past 3313 days) Posts: 5069 From: Zerus Joined: |
CFO writes:
He is in his period of slumber.
Whatever happened to Crashfrog? Why is Jar banned?
He was struck down by god (aka Percy) along with a whole bunch of other people during the 2008 admin massacre.
Ray
Oddly enough, he's still in favor with god for some reason
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